Genome-wide meta-analysis results of all included datasets

Manhattan plot of all meta-analysis results performed in ALSGene View chr. 1 on the UCSC Genome Browser View chr. 2 on the UCSC Genome Browser View chr. 3 on the UCSC Genome Browser View chr. 4 on the UCSC Genome Browser View chr. 5 on the UCSC Genome Browser View chr. 6 on the UCSC Genome Browser View chr. 7 on the UCSC Genome Browser View chr. 8 on the UCSC Genome Browser View chr. 9 on the UCSC Genome Browser View chr. 10 on the UCSC Genome Browser View chr. 11 on the UCSC Genome Browser View chr. 12 on the UCSC Genome Browser View chr. 13 on the UCSC Genome Browser View chr. 14 on the UCSC Genome Browser View chr. 15 on the UCSC Genome Browser View chr. 16 on the UCSC Genome Browser View chr. 17 on the UCSC Genome Browser View chr. 18 on the UCSC Genome Browser View chr. 19 on the UCSC Genome Browser View chr. 20 on the UCSC Genome Browser View chr. 21 on the UCSC Genome Browser View chr. 22 on the UCSC Genome Browser

GWAS overview [+]

Overview of other large-scale association studies [-]

Study Type # SNPs discovery Discovery population # Cases discovery # Ctrls discovery Follow-up population # Cases follow-up # Ctrls follow-up Featured loci
Blauw, 2008 Genome-wide CNV analysis - NL (van Es, ... [+] 406 404 - - - -
Diekstra, 2012 GWAS re-analysis: association analysis based on eQTLs 14,167 NL, BE, SE, ... [+] 2,261 8,328 FR, UK, US, ... [+] 1,307 1,835 rs4674345 (CYP27A1)
Goris, 2013 Genome-wide analysis of genetic overlap between ALS and MS 5,440,446 US, Europe ... [+] 3,762 4,886 - - - -
Iida, 2011 Gene-based tag SNP study 52,608 JP 92 233 - - - rs2275294 (ZNF512B)
Kasperaviciute, 2007 Pathway-based candidate gene study 1,372 UK 822 872 DE 579 361 -
Keller, 2014 GWAS re-analysis: heritability estimation - US, FI, IT ... [+] 1,223 1,591 - - - -
Kenna, 2013 Targeted NGS of ALS candidate loci - IE 444 311 - - - -
Kim, 2012 GWAS re-analysis: Gene ontology analysis ~550,000 US (Schymick) 276 271 IE 221 211 Pathways: Regulation of Cellular Component Organization and Biogenesis, Actin Cytoskeleton
Lesnick, 2008 GWAS re-analysis: Axon guidance pathways 4,133 US (Schymick) 275 269 - - - -
Mok, 2013 Genome-wide homozygosity analysis 511,743 FI (Laaksov ... [+] 2,017 6,918 - - - 21q22.11, 1p36.32, 5q12.3
Sha, 2011 GWAS re-analysis: Improved score test 549,062 US (Schymick) 276 271 - - - rs4363506-rs3733242 ... [+]
Sha, 2009 GWAS re-analysis: Two-locus model 549,062 US (Schymick) 276 271 - - - -
Zhang, 2010 GWAS re-analysis: Two-stage joint effects model 549,062 US (Schymick) 276 271 - - - -