ALSGene

Gene overview of all published ALS-association studies for APOE

Gene:

APOE (AD2; LDLCQ5; LPG; MGC1571)

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Protein:

apolipoprotein E (OTTHUMP00000197075; OTTHUMP00000197076; OTTHUMP00000197077; apo-E; apolipoprotein E3)

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 11 December 2010 ; ***Entries in this section are still under construction***

1. Case-Control Studies (by ethnic group)
				ALS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Al-Chalabri, 1996	UK	CL	1 (detail)	123 (40%)	Unknown	54 (-)	-	121 (-)	-	Positive
Bachus, 1997	Germany	CL	1 (detail)	151 (48%)	Unknown	55.3 (-)	-	1323 (-)	46.5 + 20 (-)	Negative
Gaillard, 1998	Overlaps with Moulard, 1996 (France)	CL	1 (detail)	32 (44%)	Unknown	-	-	99 (47%)	-	n.a.
Lacomblez, 2002	France	CL	1 (detail)	403 (42%)	Escorial	57.1 + 12.9 (-)	-	1091 (-)	-	Positive
Moulard, 1996	France	CL	1 (detail)	130 (48%)	Escorial 1	60.5 + 11 (-)	-	675 (-)	-	Positive
Penco, 2008	Italy	CL	2 (detail)	54 (48%)	Escorial 2	59.6 (54-66)	-	208 (-)	-	Positive
Zetterberg, 2008	Sweden	CL	1 (detail)	60 (-)	Escorial 2	-	-	1265 (63%)	70 (50-94)	Positive
Other/Mixed
Drory, 2001	Israel	CL	1 (detail)	100 (47%)	Escorial 2	57 + 12 (21-82)	-	133 (56%)	70 + 12 (-)	Positive
Mui, 1995	USA	CL	1 (detail)	142 (-)	Unknown	53 (-)	-	26 (-)	-	Negative
Schmidt, 2010	USA	CL	1 (detail)	417 (-)	Escorial 1	-	-	482 (-)	-	Positive
Siddique, 1998	USA	CL	1 (detail)	363 (38%)	Unknown	52.9 + 13.9 (-)	-	351 (46%)	54.7 + 13.3 (-)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based) or “PO” (population-based)
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Onset Age and Age: Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine ALS diagnosis -> "Escorial 1" (El Escorial World Federation of Neurology criteria, 1994), " Escorial 2" (Revised El Escorial World Federation of Neurology criteria, 1998), "Escorial 1+2" (El Escorial World Federation of Neurology criteria, 1994 and 1998), "Escorial" (Undefined El Escorial criteria), "Escorial+N" (Escorial Criteria, supported by neuropathological diagnosis), "O/M" (other/mixed), "Unknown" (Diagnostic criteria not specified).
Result:  Result: Overall conclusion reached by authors of the original publication (“positive” usually indicates significant association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  No data provided.





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			The ALSGene database is supported by a grant from Prize4Life in partnership with the Alzheimer Research Forum.